The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein

Abstract Background Myeloid cell leukaemia 1 (MCL1) is a pro-survival Bcl-2 family protein that plays important roles in cell survival, proliferation, differentiation and tumourigenesis.MCL1 is a fast-turnover protein that is degraded via an ubiquitination/proteasome-dependent mechanism.Although several E3 ligases have been discovered to promote th

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Birth origin differentially affects depressive-like behaviours: are captive-born cynomolgus monkeys more vulnerable to depression than their wild-born counterparts?

BackgroundAdverse early-life experience might lead to the expression of abnormal behaviours in animals and the predisposition to psychiatric disorder (e.g.major depressive disorder) in Humans.Common breeding processes employ weaning and housing conditions different from what happens in the wild.MethodsThe present study, therefore, investigated Back

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